IFIBYNE 05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
When chromatin meets splicing.
Autor/es:
KORNBLIHTT ALBERTO BLENCOWE BJ.; SCHOR IGNACIO; ALLO, MARIANO; BLENCOWE BJ.
Revista:
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Editorial:
NATURE PUBLISHING GROUP
Referencias:
Año: 2009 vol. 16 p. 902 - 903
ISSN:
1545-9985
Resumen:
Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing.
