IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
Disease-modifying immunotherapy for the management of autoimmune diabetes
Autor/es:
CARLA N CASTRO, ANDRES BARCALA TABARROZI, MAIA ANTUNICA NOGUEROL, ANA C. LIBERMAN, RICARDO A DEWEY, EDUARDO ARZT, ADIRAN E MORELLI AND MARCELO J PERONE
Revista:
NEUROIMMUNOMODULATION.
Editorial:
KARGER
Referencias:
Año: 2009
ISSN:
1021-7401
Resumen:
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that destroys the insulin-secreting beta-cells of the pancreas. It is now possible to predict those candidates that will progress to T1D before the full onset of the disease. Prevention of uncontrollable autoimmunity against beta-cells in therapies for T1D is mandatory to preserve the beta-cell mass. Therefore, immunomodulatory strategies directed to inhibiting the activity of self-reactive T cell clones as well as induction of regulatory T cells would be beneficial for prevention of T1D or recurrence of beta-cell autoimmunity against islet cell allografts. Copyright © 2010 S. Karger AG, Basel.