IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
Neuroanatomic distribution of angiotensin II-like
Autor/es:
FRENKEL L,; BEATRIZ DIMANT; ENRIQUE L. PORTIANSKY; HANS IMBODEN; HECTOR MALDONADO; ALEJANDRO DELORENZI
Revista:
CELL AND TISSUE RESEARCH
Editorial:
SPRINGER
Referencias:
Año: 2009
ISSN:
0302-766X
Resumen:
Angiotensins constitute a neuropeptidergic system that emerged early in evolution. Their classical osmoregulatory and dipsogenic functions, as well as their mnemonic actions, have been shown both in vertebrates and in some invertebrate species. Previously, we have shown that, in the euryhaline and semiterrestrial crab Chasmagnathus granulatus, water deprivation correlates with an increased level of brain angiotensin II-like neuropeptide/s (ANGII-like) and improve memory processes through ANGII receptors. We have previously proposed that the release of brain angiotensins in response to water shortages is an ancient mechanism for coordinating different functions that, together, enable organisms to cope with this environmental change. Here, we evaluated the physiological changes in ANGII-like levels in different central nervous system structures when animals are water-deprived. We first describe the neuroanatomic distribution of ANGII-like in the optic lobes and brain of Chasmagnathus granulatus. Secondly, we evaluated the physiological changes in ANGII-like distribution in different brain neuropils when animals are water-deprived. Our results indicate that ANGII-like is, in fact, a very widely distributed neuropeptide, especially in the medial protocerebrum. We found that, after 2 hours of water deprivation, ANGII-like immunoreactivity increases in the central body and decreases in the olfactory neuropil, and that after 6 hours of water deprivation, the ANGII-like immunoreactivity is markedly reduced in several brain areas. Although further experiments are needed to prove that the angiotensinergic system plays a role in the balance of body fluids in this crab, our results suggest that several functions are regulated by this neuropeptide when animals cope with water shortages.