IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
Context-dependent memory traces in the crabs' mushroom body: functional support for a common origin of high-order memory centers
Autor/es:
A SHKEDY.; A DELORENZI; A SHKEDY.; A DELORENZI; FJ MAZA ; VN PESZANO; FJ MAZA ; VN PESZANO; J SZTARKER; FF LOCATELLI; J SZTARKER; FF LOCATELLI
Revista:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Editorial:
NATL ACAD SCIENCES
Referencias:
Lugar: Washington DC, USA; Año: 2016
ISSN:
0027-8424
Resumen:
The hypothesis of a common origin for the high-order memorycenters in bilateral animals is based on the evidence that severalkey features, including gene expression and neuronal networkpatterns, are shared across several phyla. Central to this hypothesisis the assumption that the arthropods? higher order neuropilsof the forebrain [the mushroom bodies (MBs) of insects and thehemiellipsoid bodies (HBs) of crustaceans] are homologous structures.However, even though involvement in memory processeshas been repeatedly demonstrated for the MBs, direct proof ofsuch a role in HBs is lacking. Here, through neuroanatomical andimmunohistochemical analysis, we identified, in the crab Neohelicegranulata, HBs that resemble the calyxless MBs found inseveral insects. Using in vivo calcium imaging, we revealed training-dependent changes in neuronal responses of vertical and mediallobes of the HBs. These changes were stimulus-specific, and,like in the hippocampus and MBs, the changes reflected the contextattribute of the memory trace, which has been envisioned asan essential feature for the HBs. The present study constitutesfunctional evidence in favor of a role for the HBs in memory processes,and provides key physiological evidence supporting a commonorigin of the arthropods? high-order memory centers.