IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease
Autor/es:
GERARDO MORFINI; GUSTAVO PIGINO; CARINA WEISSMANN; NADINE SCHMIDT; STEFAN KINS
Revista:
BRAIN RESEARCH BULLETIN
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2016
ISSN:
0361-9230
Resumen:
Intracellular trafficking events powered by microtubule-based molecular motors facilitate the targeteddelivery of selected molecular components to specific neuronal subdomains. Within this context, weprovide a brief review of mechanisms underlying the execution of axonal transport (AT) by conventionalkinesin, the most abundant kinesin-related motor protein in the mature nervous system. We emphasizethe biochemical heterogeneity of this multi-subunit motor protein, further discussing its significancein light of recent discoveries revealing its regulation by various protein kinases. In addition, we raiseissues relevant to the mode of conventional kinesin attachment to cargoes and examine recent evi-dence linking alterations in conventional kinesin phosphorylation to the pathogenesis of adult-onsetneurodegenerative diseases.