IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
Pedunculopontine arousal system physiology?Effects of psychostimulant abuse
Autor/es:
URBANO FJ; BISAGNO V; GONZALEZ B; RIVERO-ECHETO MC; MUÑIZ JA; LUSTER BR; DONOFRIO S; MAHAFFEY S; GARCIA-RILL E
Revista:
Sleep Science
Editorial:
Elsevier
Referencias:
Lugar: New York; Año: 2015 vol. 8 p. 162 - 168
ISSN:
1984-0659
Resumen:
This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to be involved in the animal?s voluntary search for psychostimulants. Every PPN neuron is known to generate gamma band oscillations. Voltage-gated calcium channels are key elements in the generation and maintenance of gamma band activity of PPN neurons. Calcium channels are also key elements mediating psychostimulant-induced alterations in the thalamic targets of PPN output. Thus, the PPN is a key substrate for maintaining arousal and REM sleep, but also in modulating psychostimulant self-administration