IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder.
Autor/es:
D'ONOFRIO S; KEZUNOVIC N; HYDE JR; LUSTER BR; MESSIAS E; URBANO FJ----- # URBANO FJ & GARCIA-RILL E CONTRIBUTED EQUALLY AS LAST AUTHORS.; GARCIA-RILL E------ # URBANO FJ & GARCIA-RILL E CONTRIBUTED EQUALLY AS LAST AUTHORS
Revista:
JOURNAL OF NEUROPHYSIOLOGY
Editorial:
AMER PHYSIOLOGICAL SOC
Referencias:
Lugar: Bethesda; Año: 2015 vol. 113 p. 709 - 719
ISSN:
0022-3077
Resumen:
Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders are also characterized by sleep dysregulation, suggesting a role for the reticular activating system (RAS). The discovery of gamma-band activity in the pedunculopontine nucleus (PPN), the cholinergic arm of the RAS, revealed that such activity was mediated by high-threshold calcium channels that are regulated by NCS-1. We hypothesized that NCS-1 normally regulates gamma-band oscillations through these calcium channels and that excessive levels of NCS-1, such as would be expected with over-expression, decrease gamma-band activity. We found that PPN neurons in rat brain slices manifested gamma-band oscillations that were increased by low levels of NCS-1 but suppressed by high levels of NCS-1. Our results suggest that NCS-1 over-expression may be responsible for the decrease in gamma-band activity present in at least some schizophrenia and bipolar disorder patients.