IFIBYNE 05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
Pedunculopontine arousal system physiology ? Implications for insomnia
Autor/es:
GARCIA-RILL E; LUSTER BR; MAHAFFEY S; BISAGNO V; URBANO FJ
Revista:
Sleep Science
Editorial:
Production and Hosting by Elsevier B.V. on behalf of the Brazilian Association of Sleep
Referencias:
Año: 2015 vol. 8 p. 92 - 99
ISSN:
1984-0063
Resumen:
We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia.
