The connection between splicing and cancer

SREBROW, A; KORNBLIHTT, A.R

JOURNAL OF CELL SCIENCE

The Company of Biologists

Año: 2006 vol. 119 p. 2635 - 2641

0021-9533

Alternative splicing is a crucial mechanism for generating protein diversity. Different splice variants of a given protein can display different and even antagonistic biological functions. Therefore, appropriate control of their synthesis is required to assure the complex orchestration of cellular processes within multicellular organisms. Mutations in cisacting splicing elements or changes in the activity of regulatory proteins that compromise the accuracy of either constitutive or alternative splicing could have a profound impact on human pathogenesis, in particular in tumor development and progression. Mutations in splicing elements, for example, have been found in genes such as LKB1, KIT, CDH17, KLF6and BRCA1, and changes in trans-acting regulators can affect the expression of genes such as Ron, RAC1and CD44.