IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
Dissociation between memory reactivation and its behavioral expression: scopolamine interferes with memory expression without disrupting long-term storage.
Autor/es:
CAFFARO P; SUÁREZ LD; BLAKE MG; DELORENZI A
Revista:
NEUROBIOLOGY OF LEARNING AND MEMORY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 98 p. 235 - 245
ISSN:
1074-7427
Resumen:
The reconsolidation hypothesis has challenged the traditional view of fixed memories afterconsolidation. Reconsolidation studies have disclosed that the mechanisms mediating memoryretrieval and the mechanisms that underlie the behavioral expression of memory can bedissociated, offering a new prospect for understanding the nature of experimental amnesia.The muscarinic antagonist scopolamine has been used for decades to induce experimentalamnesias The goal of the present study is to determine whether the amnesic effects ofscopolamine are due to storage (or retrieval) deficits or, alternatively, to a decrease in the longtermmemory expression of a consolidated long-term memory. In the crab Chasmagnathusmemory model, we found that scopolamine-induced amnesia can be reverted by facilitationafter reminder presentation. This recovery of memory expression was reconsolidation specificsince a reminder that does not triggers reconsolidation process did not allow the recovery. Ahigher dose (5μg/g) of scopolamine induced an amnesic effect that could not be revertedthrough reconsolidation, and thus it can be explained as an interference with memory storageand/or retrieval mechanisms. These results, showing that an effective amnesic dose ofscopolamine (100ng/g) negatively modulates long-term memory expression but not memorystorage in the crab Chasmagnathus, are consistent with the concept that dissociable processes underlie the mechanisms mediating memory reactivation and the behavioral expression ofmemory.