IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
Dissecting mechanisms of reconsolidation: octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus
Autor/es:
LAURA KACZER; MARTÍN KLAPPENBACH; HÉCTOR MALDONADO
Revista:
EUROPEAN JOURNAL OF NEUROSCIENCE
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2011
ISSN:
0953-816X
Resumen:
Ample evidence suggests that, when reactivated by a reminder, a consolidatedmemory may return to a labile state and needs to be stabilized again in order to persist, aprocess known as reconsolidation. In a previous study, performed in the crabChasmagnathus, we found a dual role for the biogenic amine octopamine (OA) duringmemory consolidation. On the one hand, it was necessary for appetitive memoryformation and, on the other, it had a deleterious effect on aversive memoryconsolidation. Thus, OA could be a good candidate to dissect the neurochemicalmechanisms of appetitive and aversive reconsolidation. Here, we initially characterizedthe reconsolidation of an appetitive memory. Then, we compared appetitivereconsolidation with its aversive counterpart regarding the implication of OA in theseprocesses, and contrasted them with previous findings obtained in the consolidationphase. Our results demonstrate that appetitive reconsolidation takes place when animalsare re-exposed to the training context, as shown by the amnesic effect of cycloheximidewhen applied before the reminder. In addition, the no-reinforcement during thereminder is a necessary condition for appetitive reconsolidation to occur. Remarkably,appetitive reconsolidation is neither impaired by OA receptor antagonists nor facilitatedby exogenous OA, whereas aversive reconsolidation can be interfered with by OAadministration. Thus, our results indicate that appetitive reconsolidation does notinvolve OA signalling, while aversive reconsolidation is negatively modulated by OA.All in all, these results could constitute a step towards the identification of particularfeatures of appetitive and aversive reconsolidation.