Effect of chemotherapy on endocrine testicular function during childhood and puberty in patients with acute lymphoblastic leukaemia or non-Hodgkin lymphoma: a prospective, longitudinal study

AROZARENA DE GAMBOA, MARIA; AVERSA L; BRENZONI L; GUTIERREZ M.; REY RA; PRADA S; BEDECARRÁS , PATRICIA; GRINSPON R P

Congreso; XXIX Reunión Sociedad Latinoamericana Endocrinología Pediátrica; 2020

Introduction: Chemotherapy can have variable effects according to the proliferative state of cell populations. Testicular Sertoli cells show differences in proliferative status between childhood and puberty.Aim: To determine if there is a differential effect of chemotherapy on Sertoli cell function between children and adolescents with hematologic malignancies during and after treatment. Secondarily, testosterone (T) and gonadotropins were evaluated.Methods: prospective cohort study in children with acute lymphoblastic leukaemia or non-Hodgkin lymphoma. Serum levels of AMH and FSH (direct and indirect marker of Sertoli cells, respectively) and of T and LH (direct and indirect markers of Leydig cells) were evaluated during chemotherapy and during 24 months after the end of the treatment (tx). Results were analysed according to pubertal stage and expressed as median (range).Results: 17 prepubertal boys, age 6.1 yr (0.63-10) and 5 pubertal, age 13.3 yr (11.7-14.8) were analysed. Follow-up was 4.4 ± 0.74 years.In prepubertal boys pre-tx AMH was -0.37 (-1.87?1.19), at 3 months (m): 0.29 (-1.16?1.90), 6 m: 0.00 (-1.1?1.18), 12 m: -0.23 (-0.8?1.50), 24 m (end tx): -0.88 (-0.34?1.69). 3 months after end of treatment: 0.68 (-0.54?2.01), 12 m: 1.09 (-0.39?3.94) and 24 m: 0.83 (-0.85?5.12). Six of them started puberty during follow-up, after the end of chemotherapy. None had an AMH