CEDIE 05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Functional assessment of testicular Sertoli cell function in chemotherapytreated prepubertal and pubertal male survivors of childhood cancer.
Autor/es:
MARJORIE MORALES BAZURTO; MAR¨ªA G. BALLERINI; MARIA G. ROPELATO; BERGADA IGNACIO; RODOLFO A. REY; ROMINA P. GRINSPON
Lugar:
Costa de Sauipe, Bahía, Brazil
Reunión:
Congreso; Reunión Sociedad Latinoamericana Endocrinología Pediátrica.; 2010
Institución organizadora:
Sociedad Latinoamericana Endocrinología Pediátrica.
Resumen:
Background: Male germ cells are highly sensitive to chemotherapy,
whereas quiescent Leydig cells seem to be less affected in
prepubertal boys. Sertoli cells have rarely been studied. Objective:Male germ cells are highly sensitive to chemotherapy,
whereas quiescent Leydig cells seem to be less affected in
prepubertal boys. Sertoli cells have rarely been studied. Objective:Objective:
To assess pituitary-testicular function, with emphasis on Sertoli cell
function, in boys and adolescents with extragonadal tumors having
received chemotherapy exclusively. Methods: A retrospective analysis
including 51 patients treated <10yr and 38 treated between 1018
yr. FSH and AMH levels were the primary endpoints. LH and testosterone
were also assessed. Results: In 35/51 patients treated <10yr,
evaluation before puberty (9.7±2.3 yr; 3.0±2.6 yr post-chemotherapy)
showed normal AMH in all, with mild elevation of FSH in 31.4% and
LH in 14.3%. In 30/51 cases treated <10 yr, evaluation at pubertal
age (15.0±2.2 yr; 8.8±3.5 yr post-chemotherapy) showed low AMH
in 3.8%, low testosterone in 13.3% and mildly elevated FSH and LH
in 13.3%. In 38 patients treated during puberty, analysis 5.0±4.5 yr
post-chemotherapy showed normal AMH in all, low testosterone
and moderately elevated LH in 5.2%, and elevated FSH in 28.9%.Methods: A retrospective analysis
including 51 patients treated <10yr and 38 treated between 1018
yr. FSH and AMH levels were the primary endpoints. LH and testosterone
were also assessed. Results: In 35/51 patients treated <10yr,
evaluation before puberty (9.7±2.3 yr; 3.0±2.6 yr post-chemotherapy)
showed normal AMH in all, with mild elevation of FSH in 31.4% and
LH in 14.3%. In 30/51 cases treated <10 yr, evaluation at pubertal
age (15.0±2.2 yr; 8.8±3.5 yr post-chemotherapy) showed low AMH
in 3.8%, low testosterone in 13.3% and mildly elevated FSH and LH
in 13.3%. In 38 patients treated during puberty, analysis 5.0±4.5 yr
post-chemotherapy showed normal AMH in all, low testosterone
and moderately elevated LH in 5.2%, and elevated FSH in 28.9%.Results: In 35/51 patients treated <10yr,
evaluation before puberty (9.7±2.3 yr; 3.0±2.6 yr post-chemotherapy)
showed normal AMH in all, with mild elevation of FSH in 31.4% and
LH in 14.3%. In 30/51 cases treated <10 yr, evaluation at pubertal
age (15.0±2.2 yr; 8.8±3.5 yr post-chemotherapy) showed low AMH
in 3.8%, low testosterone in 13.3% and mildly elevated FSH and LH
in 13.3%. In 38 patients treated during puberty, analysis 5.0±4.5 yr
post-chemotherapy showed normal AMH in all, low testosterone
and moderately elevated LH in 5.2%, and elevated FSH in 28.9%.
Conclusions: Like Leydig cells, Sertoli cells have low sensitivity to
chemotherapy in prepubertal and pubertal males. Pubertal elevation
of FSH in a subset of patients might be due to germ cell loss.Like Leydig cells, Sertoli cells have low sensitivity to
chemotherapy in prepubertal and pubertal males. Pubertal elevation
of FSH in a subset of patients might be due to germ cell loss.
