IGF1R nuclear localization in pediatric glioblastoma: phenotypic characterization and the use of IGF1R/IR inhibitor OSI906 as a targeted therapy

MARTIN AYELEN

Conferencia; GH/IGF-1 action in health, disease and aging; 2020

The insulin-like growth factor 1 receptor (IGF-1R) plays important roles cancer biology, and its nuclear localization has been described as adverse prognostic factor in different tumors. In a previous study we have demonstrated that, in pediatric gliomas, IGF1R nuclear localization is associated with higher grade tumors and also related with worst clinical outcome of those patients. Here, we explore the role of IGF1R intracellular localization comparing two glioblastoma cell lines that only differ on IGF1R capacity to translocate to the nucleus. We demonstrated that, in vitro, IGF1R nuclear localization enhances glioblastoma cell motility and metabolism without affecting their proliferation. The metabolic advantage given by IGF1R nuclear localization favors tumor development, contributing to a more aggressive phenotype but also renders the cells sensitive to a targeted therapy with OSI906.