Thyroid function following hemithyroidectomy in a pediatric cohort.

PAPENDIECK P; CHIESA A.; MASNATA, MARIA E.; BERGADÁ I

Florianopolis

Congreso; XXVIII Congreso de la Sociedad Latinoamericana de Endocrinologia Pediatrica; 2019

Sociedad Latinoamericana de Endocrinologia Pediatrica SLEP

Background:Studies about thyroid function following hemithyroidectomy are scarce in the literature and no studies include pediatric population.Objective:To describe thyroid function in pediatric patients who underwent a hemithyroidectomy. Design:Retrospective cohort study.Patients and methods: Among the 38 patients who underwent hemithyroidectomy from 2006 to 2018, a total of 24 patients with available data who were followed up for more than a year and who were free of treatment at consultation were included in the analysis.All patients were analyzed for age, sex, surgical indication and final pathologic analysis. Thyroid function (TSH, free T4 (fT4) and antithyroid antibodies (Ab)) were measured preoperative (P1) and postoperative (1-3 (P2) and 12-36 (P3) months). Paired Anova test was performed to evaluate TSH and fT4 levels (p 10mIU/L (overt hypothyroidism) and 7 with TSH 5-10 mIU/L were assumed as subclinical hypothyroidism with different criteria and initiated replacement with LT4 (only 1 was reevaluated 6 years after showing a normal thyroid function). The remaining 12 patients who were not treated (final cohort) were reevaluated at a minimum of 12 months after surgery (P3). Median TSH and fT4 at P1 were 1.2 mIU/L (r:0.8-2.2) and 1.2 ng/dl (r: 1-1.9), respectively. TSH at P2 showed a significant elevation when compared to TSH at P1 (p