Prevalence of hypogonadism in prepubertal boys with cryptorchidism

GOTTLIEB S.; GRINSPON R P; REY RA; BEDECARRÁS P

Chicago

Congreso; Endocrine Society?s 100th Annual Meeting; 2018

Endocrine Society

The functional capacity of the testes in prepubertal boys with cryptorchidism before treatment has received very little attention. The assessment of testicular function at diagnosis could be helpful in the understanding of the pathophysiology of cryptorchidism and in the evaluation of the effect of treatment.Anti-Müllerian hormone (AMH) is a well-accepted Sertoli cell biomarker to evaluate testicular function during childhood without the need for stimulation tests. To assess testicular function in prepubertal children with cryptorchidism before orchiopexy, by determining serum AMH. We also evaluated serum gonadotropins and testosterone and looked for associations between testicular function and the clinical characteristics of cryptorchidism.Design: Retrospective, cross-sectional, analytical study. All clinical charts of patients admitted at the outpatient clinic (years 2000 to 2017) and recorded in our database with the diagnosis of cryptorchidism, were eligible. Main outcome measure: Serum concentration of AMH (EIA AMH/MIS®, Beckman-Coulter Co). Secondary outcome measures: Serum LH, FSH and testosterone. For comparison, serum hormone levels from a normal population of 179 apparently normal prepubertal boys were used. Inclusion criteria: Normal virilisation and assessment at prepubertal age and before orchidopexy. Exclusion criteria: Patients with other known disorders affecting the gonadal axisMedian AMH SDS was below 0 in both the bilaterally (Wilcoxon signed rank test, P