Adiponectin as a Marker of Peripheral Insulin Resistance in Adolescents with Polycystic Ovarian Syndrome (PCOS) and as a Tool to Suspect Insulin Receptor Defects

BALLERINI, MARÍA GABRIELA; SCAGLIA, PAULA; FREIRE, ANALIA; ARCARI, ANDREA; BERGADÁ IGNACIO; GRYNGARTEN, MIRTA; BENGOLEA VIVIANA ; ROPELATO, MARÍA GABRIELA

Atenas

Congreso; 57th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE); 2018

European Society for Paediatric Endocrinology (ESPE)

P2-P355 Decreased serum adiponectin levels are associated with obesity and peripheral insulin resistance (IR). PCOS is characterized by hyperandrogenism and chronic anovulation and frequently is associated to IR. Some defects of Insulin Receptor have been proposed as mechanisms to explain ovarian hyperandrogenism in PCOS. Objectives: To explore adiponectin levels in adolescents with PCOS and to evaluate if adiponectin would identify potential patients with hyperandrogenism associated to defects in the insulin receptor or its intracellular signal pathway. Patients and Methods: Prospective cross-sectional study. Twenty PCOS adolescents (16.4±2 years) diagnosed according to AES criteria and 10 healthy normal cycling adolescents (16.0±1.5 years) were studied. Fasting glucose, insulin, adiponectin, androgens (total and free testosterone, androstenedione), were measured. HOMA-IR > 2.5 was used a surrogate of IR. Results: 11/20 (55%) PCOS patients showed IR (4 with normal BMI and 7 with high BMI). There were no differences between patients with or without IR in hirsutism score, menstrual cycle abnormalities or in the grade of hyperandrogenemia. Adiponectin levels in PCOS patients with increased BMI and insulin resistance were lower than in both PCOS and controls with normal BMI (ANOVA on way pC (p.Leu1150Pro)). This variant is classified as likely pathogenic applying ACMG guidelines. Molecular study of insulin receptor gene from the other patient is currently under process. Conclusions: Adiponectin levels are negatively associated with BMI and the severity of peripheral insulin resistance, while serum androgens do not seem to be related to them. Unexpectedly high levels of Adiponectin in patients with PCOS who exhibit insulin resistance should lead towards molecular studies to rule out insulin receptor defects.