The role of basal biochemical tests in the diagnostic work-out of growth hormone deficiency (GHD) in the newborn period

BALLERINI MG; RODRIGUEZ ME; BERGADÁ I; GOTTA G; ROPELATO MG; BRASLAVSKY D; KESELMAN A

Washington

Congreso; 10th International Meeting of Pediatric Endocrinology; 2017

The global community of pediatric endocrinology

Objectives: GHD diagnosis represents a challenge in neonates in whom provocative tests are difficult to implement. The accuracy of basal GH-IGFs biomarkers in the diagnostic workout of GHD in neonates is still controversial.To assess the diagnostic accuracy of basal GH/IGF-I/IGFBP3 concentrations for GHD diagnosis and to evaluate serum GH usefulness under hypoglycemia in neonates.Methods: Retrospective case-control study of 25 full-term neonates [median age (m): 25 days] with confirmed GHD based on growth retardation, stimulated GH