Overtreatment during the first six months of life in congenital hypothyroidism: Impacto on neurocognition

ENACAN R.; PARDO CAMPOS ML. , ; ANA CHIESA,; I BERGADA,

Buenos Aires

Congreso; XXVI Congreso de la Sociedad Latinoamericana de Endocrinologia Pediatrica; 2016

Sociedad Latinoamericana de Endocrinologia Pediatrica SLEP

O-53Overtreatment during the First Six Monthsin Congenital Hypothyroidism: Impact onNeurocognitionEBackground: Early diagnosis and treatment of Congenital hypothyroidism(CH) prevents mental retardation. Although initialtreatment with high doses of levothyroxine (LT4) is recommended,moderate hyperthyroxinemia with suppressed TSH during thefirst months of some patients is difficult to avoid. Whether this isinnocuous or constitutes a risk factor for neurocognitive impairmentis controversial.Objective: To evaluate the cognitive outcome at age 9?10 ofearly detected and treated CH in whom suppressed TSH and moderatehyperthyroxinemia were present during the first six monthsof treatment.Patients and Methods: We retrospectively reviewed age, TSH,T4 levels at diagnosis a, LT4 initial doses, etiology, symptoms ofhyperthyroidism and T4 levels attained at 2 and 6 months of 35CH patients early detected and regularly followed up.Patients were considered overtreated (OT) if TSH was persistently40 uUI/ml (OT:89.5%, NOT:93.8%) and T4