CONICET | Buscador de Institutos y Recursos Humanos

In patients with CAIS, where a functional androgen receptor is absent, ablunted LH pattern is observed after birth, revealing the importance of thehypothalamic androgen imprinting for the posnatal gonadotropin secretionin males. The regulation of inhibin B (InhB) and Anti-müllerian hormone(AMH) production by Sertoli cells during the prepubertal quiescent periodstill remains speculative. CAIS might represent a useful model to betterunderstand androgen action on the regulation of these peptides from birthto early puberty. For this reason, we investigated the secretion of InhB andAMH in patients with CAIS from birth through infancy up to early stages ofpuberty (Tanner II). Seven 46,XY girls with CAIS (age range:2 days to 9.5yr) were included in this observational, retrospective study. Levels of LH,FSH, T, Pro-αC, InhB and AMH were determined before gonadectomy. Aconcomitant increase in InhB (546 and 639 pg/ml) and FSH (1.4 and 2.2 IU/l),levels was observed in two patients, 2-day-old and 5,2 yr, respectively. HighInhB (472 and 401 pg/ml) with normal FSH (2.2 and 1.6 IU/l, respectively)levels were observed in two patients at early puberty. Whereas, normal InhB(172 and 146 pg/ml) levels were associated with high FSH (6.9 and 8.8 IU/l,respectively) in two out of three patients during childhood. ProαC was increasedin two patients and InhB/ProαC ratio was altered in 5 patients. AMHdid not always follow variations either in InhB or FSH levels. In conclusion,in the absence of an active androgen receptor there is an abnormal regulationof Sertoli cell peptide secretion. However, lack of a homogeneous pattern forthis alteration, does not allow establishing the mechanism involved, that stillneeds to be clarified.