GnRH Infusion in Females with Hypogonadotropic Hypogonadism.

ANALIA FREIRE; ANDREA ARCARI; GRINSPON RP; MARÍA GABRIELA BALLERINI; NORA SANGUINETTI; BERGADA IGNACIO; ESCOBAR MARÍA EUGENIA; MARÍA GABRIELA ROPELATO; GRYNGARTEN MIRTA

Puerto Varas

Congreso; XXV Annual Meeting of the Latin American Pediatric Endocrinology Society (SLEP); 2015

Sociedad Latinoamericana de endocrinología pediátrica

Background: Hypogonadotropic hypogonadism (HH) in femalesis an uncommon and heterogeneous condition. There is littledata regarding biochemical profile of gonadotropins to furthersubstantiate the diagnosis.Objective: To evaluate the gonadotropaic secretion profile afterGnRH infusion in a female cohort diagnosed with HH.Patients and Methods: GnRH iv infusion test (0?120 min)were performed in 17 patients (17.5 ± 2.3 years) with suspicious ofHH for pubertal delay or primary amenorrhea associated with:Group1 (G1)- acquired or congenital pituitary pathology (n = 7)or G2- hypo/anosmia (n = 6) or G3-lack of spontaneous pubertalprogression after a brief estrogenic therapy or lack of pubertal clinicaland biochemical progression for one year (n = 4). LH, FSH at0, 15, 30, 45, 60 and 120 min (IFMA) and basal Estradiol (ECLIA)were determined. Basal pubertal cutoffs were defined as FSH >1.5IU/L and basal LH >0.3 IU/L.Results: Basal FSH