Optimal Strategy for Ovarian Function Assessment in Girls with Central Precocious Puberty before and During GnRH Analogue Treatment

FREIRE A; GRYNGARTEN M; ARCARI A; BALLERINI MG; LORETI N; AMBAO V; BERGADÁ I; CAMPO S; ROPELATO MG

Barcelona

Congreso; 54th Annual Meeting of the ESPE European Society for Paediatric Endocrinology; 2015

European Society for Paediatric Endocrinology

Background:The degree of suppression of the pituitaryovarian axis in girls with central precocious puberty (CPP) under GnRH analogue (GnRHa) treatment is usually assessed at pituitary levels. However, the extent of ovarian function suppression under GnRHa treatment has not been evaluated. Objective:To evaluateovarian activity in CPP girls before and during treatment with GnRHa. Patients and methods: In this prospective study, 11 CPP girls naıve of treatment were included. Serum LH, FSH, estradiol (E2, ECLIA) and inhibin B (INH-B, ELISA) weremeasured at baseline, 3 and 24 h after depot Triptorelin acetate 3.75 mg IM administration at the first and after 4th ,7th and 13th doses. Samples were obtained at 3 and 24 h at the time of maximal gonadotrophin and ovarian responses respectively. Results:3h after the first GnRHa dose LH and FSH (meanGSEM) increased significantly over baseline (1.9G0.79 to 22.2 IU/l and 4.6 0.46 IU/l to 19.9+-1.9 IU/l, P