Body Mass Index (BMI) evaluation in girls with idiopathic central precocious puberty (ICPP) during and after treatment with GnRH analogs (GnRHa)

ARCARI, ANDREA; FREIRE, ANALÍA; BALLERINI, MARÍA GABRIELA; ROPELATO, MARÍA GABRIELA; BERGADÁ, IGNACIO; ESCOBAR, MARÍA EUGENIA;; GRYNGARTEN, MIRTA

Milan

Congreso; 9th Joint Meeting of Pediatric Endocrinology; 2013

ENDO, SLEP

Page 329 Abstr P2 d2 1061 Introduction: GnRH analogs have been used in treatrnent ofIepp for several decades. Their effectiveness on adult height improvement has been widely studied. However, their impact on BMI is still controversial. Objective: To assess BMI in lepp girls during treatrnent with GnRHa and when reaching adult height. Metbods: A retrospective study of 117 le?? girls, treated for a minimum of2 years was performed (mean age at diagnosis: 7.6, range 2.7-9.2 years). BMISOS at basal, 1 and 2 years of GnRHa treatment was analyzed. In addition, 60 girls were also evaluated when adult height was reached. Patients were categorized according to BMI at the start of therapy into 3 groups: normal weight (NW, n=56), overweight (OW, n=43) and obese (OB, n=18). Changes in BMI-SOS were analyzed by ANOVA for repeated measurements. Results: Basal SOS BMI (mean ±SO) was: in the NW group 0.29±O.7, in the OW group 1.54±O.2 and in the OB group 2.41±O.3. NW girls significantly increased BMI between basal and 1 year, mean: 0.42 SOS (p< 0.001). There were no differences in BMI between 1 and 2 years of treatrnent. OW girls showed a significant BMI increase (mean 0.2 SOS) at I year (p< 0.05) without differences between 1 and 2 years of treatment. In the OB group there was no difference in BMI along treatrnent. Girls who had achieved adult height showed a significant decrease in BMI compared with the start of GnRHa (mean difference 0.56 SO -p< 0.001) and compared to BMI at I year oftreatment (mean difference 0.75, (p< 0.001). Conclusion: Moderate increment in BMI was observed at 1 year of GnRHa treatment which persisted at 2 years of treatrnent in normal and overweight lepp girls. However, no further increment in BMI was observed in already obese girls. Although changes observed on BMI throughout the first years of GnRHa treatment do occur, this does not lead to further obesity since a significant improvement on BMI is observed when these girls achieve adult height.