Prevalence of Polycystic Ovarian Syndrome (PCOS) in Adolescents with History of Idiopathic Central Precocious Puberty (ICPP

GRYNGARTEN, MIRTA; ESCOBAR, MARÍA EUGENIA;; ARCARI, ANDREA; FREIRE, ANALÍA; BALLERINI, MARÍA GABRIELA; ROPELATO, MARÍA GABRIELA; BERGADÁ, IGNACIO

Montevideo

Congreso; XXIII Annual Meeting,of the Pediatrics Endocrinogy Latinoamerican Society (SLEP); 2012

Pediatrics Endocrinogy Latinoamerican Society

PCOS in reproductive age ranges between 5 and 10%. Data about PCOS in adolescents with history of ICPP are controversial; several authors found increased incidence in patients treated with GnRH analogues (GnRHa). Objective: To evaluate the prevalence of PCOS in adolescents with history of ICPP and its relation with GnRHa treatment. Subjects: 54 girls with history of ICPP were divided into two groups. Group (GA), (n=29) treated with GnRHa, chronological age (CA) 16.3±1.7 years and group B (GB) (n=25) untreated girls, CA 14.6±2.1 years. Age at menarche (AM), Gynecological age (GyA), menstrual cycles characteristics, body mass index (BMI) and clinical hyperandrogenism at least three years after menarche were analized. Serum testosterone and androstenedione were measured by ECLIA and RIA respectively. PCOS was diagnosed according to Androgen Excess Society Consensus (AESC). Results (mean ± SD): AM in GA was 9.5±0.4 and in group B was 11.7±0.8 years (p<0.001), GyA was 4.48±1.9 in GA and 5.1±2.1 years in GB(p=ns). BMI in GA was 22.8±4.6 and 24.7±4.9 in GB (p=ns). Fourteen of 54 patients (26%) met the AESC criteria for PCOS. Prevalence of PCOS: GA 17.2% vs GB 36% (p=ns). Conclusion: A high prevalence of PCOS is found in girls with history of ICPP, however this is not related to treatment with GnRHa.