Changes in serum inhibin B levels after GnRH agonist stimulation in girls with Precocious Pubertal Development.

A. FREIRE; N. LORETI,; M. ESCOBAR; M. GRYNGARTEN; M. BALLERINI; A. ARCARI; I. BERGADÁ; S. CAMPO; M. ROPELATO

Cartagena de indias

Congreso; XXII Congreso de la Sociedad Latinoamericana de Endocrinología Pediátrica (SLEP); 2011

SLEP

Changes in serum Inhibin B levels after GnRH agonist stimulation in girls with precocious sexual development. A . Freire, N. Loreti, ME. Escobar, M. Gryngarten, MG Ballerini, A. Arcari, I. Bergadá, S. Campo, MG. Ropelato. Precocious pubertal development includes a spectrum of maturity of ovarian axis between non progressive forms of idiopathic premature thelarche (IPT) and true central precocious puberty (CPP). There is scant information on basal Inhibin B (InhB), an early marker of follicular development, in these entities and no information is available after a GnRH analogue (GnRHa) test. Objective: To evaluate InhB levels under GnRHa test as an evidence of the ovarian axis maturity in these patients. Methods: 33 girls aged 5.5-8.5 yr, breast development stage 3 (23=CPP and 10=IPT) underwent Triptorelin test (0.1 mg/m² sc), with blood sampling at 0-3-24h for LH and FSH (IFMA) and at 0-24h for Estradiol (E2)(ECLIA) and InhB (ELISA) measurements. Results: At baseline, CPP girls had higher LH, FSH and InhB levels (p