CEDIE   05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Changes in serum inhibin B levels after GnRH agonist stimulation in girls with Precocious Pubertal Development.
Autor/es:
A. FREIRE; N. LORETI,; M. ESCOBAR; M. GRYNGARTEN; M. BALLERINI; A. ARCARI; I. BERGADÁ; S. CAMPO; M. ROPELATO
Lugar:
Cartagena de indias
Reunión:
Congreso; XXII Congreso de la Sociedad Latinoamericana de Endocrinología Pediátrica (SLEP); 2011
Institución organizadora:
SLEP
Resumen:
Changes in serum Inhibin B levels after GnRH agonist stimulation in girls with precocious sexual development.
A . Freire, N. Loreti, ME. Escobar, M. Gryngarten, MG Ballerini, A. Arcari, I. Bergadá, S. Campo, MG. Ropelato.
Precocious pubertal development includes a spectrum of maturity of ovarian axis between non progressive forms of idiopathic premature thelarche (IPT) and true central precocious puberty (CPP). There is scant information on basal Inhibin B (InhB), an early marker of follicular development, in these entities and no information is available after a GnRH analogue (GnRHa) test.
Objective: To evaluate InhB levels under GnRHa test as an evidence of the ovarian axis maturity in these patients.
Methods: 33 girls aged 5.5-8.5 yr, breast development stage 3 (23=CPP and 10=IPT) underwent Triptorelin test (0.1 mg/m² sc), with blood sampling at 0-3-24h for LH and FSH (IFMA) and at 0-24h for Estradiol (E2)(ECLIA) and InhB (ELISA) measurements.
Results: At baseline, CPP girls had higher LH, FSH and InhB levels (p