CEDIE   05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Anti –Müllerian Hormone (AMH) in patients with congenital adrenal hyperplasia (CAH).
Autor/es:
ANDREA ARCARI; BEDECARRÁS , PATRICIA; GERMÁN IÑÍGUEZ; HERNANDEZ MARIA ISABEL; ANA ROCHA; GRINSPON R; FIGUEROA GACITUA V.; ANDREA FORRESTER; MARÍA JOSÉ RIAL; BERGADÁ , IGNACIO; ETHEL CODNER; MERICQ VERONICA; ESCOBAR MARÍA EUGENIA; GRYNGARTEN MIRTA; REY RA
Lugar:
Cartagena
Reunión:
Congreso; XXII Congreso Sociedad Latinoamericana de Endocrinología Pediátrica; 2011
Institución organizadora:
Sociedad Latinoamericana de Endocrinología Pediátrica
Resumen:
Introduction: Hyperandrogenism in prepubertal and pubertal girls is a risk factor for polycystic ovary syndrome (PCOS). Women with CAH, the most frequent cause of hyperandrogenism, may develop PCOS. AMH is elevated and represents a useful marker for the diagnosis of PCOS. Objective: To determine if serum AMH levels are elevated in girls with CAH Materials and methods:  A cross-sectional study in 38 patients with non classical (NC) CAH (6 prepubertal [PP], 32 pubertal [P] ) and 39 patients with classical (C) CAH (18 PP and 21P) was done. AMH levels were determined by ELISA and compared with AMH levels of normal girls (69 PP and 223 P). Results: AMH levels are showed in the table.   Non classical CAH (NC) Classical CAH (C) Normal (N)   Prepubertal girls 41.9±21.9 25.7±24.8 22.4±15.6 ANOVA P=0.003 Tukey P<0.05  NC vs N Pubertal girls 36.9±38.2 23.4±19.7 21.1±16.3 Kruskal-Wallis P=0.005 Dunn P<0.01 NC vs N   Conclusion: AMH levels are elevated in patients with non classical CAH, suggesting an increased mass of early antral follicles probably due to an increased androgen milieu. In patients with classical form of CAH this increment is not observed probably due to early corticosteroid treatment which reduces androgen levels. A longitudinal study would be necessary to evaluate the usefulness of this increment to predict evolution to PCOS.