CEDIE 05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
capítulos de libros
Título:
Sperm Pathology:pathogenic mechanisms and fertility potential in assisted reproduction
Autor/es:
CHEMES H; RAWE V.Y.
Libro:
Male Infertility, Diagnosis and Treatment
Editorial:
Informa UK Ltd.
Referencias:
Lugar: Londres; Año: 2006;
Resumen:
Sperm pathology is the discipline that characterizes
structural and functional deficiencies in spermatozoa.
It is not just another denomination for
abnormal sperm morphology; it is rather a new
concept in which a multidisciplinary approach is
applied to the precise description of sperm abnormalities
and the understanding of the pathogenic
mechanisms that underlie abnormal sperm
appearance. Used jointly with classical sperm morphology
(in particular the strict criteria), it allows
a clear appreciation of what is wrong with
abnormal sperm shapes and facilitates a rational
approach to the use of abnormal spermatozoa in
assisted reproduction. The distinction between
non-specific anomalies and systematic defects of
genetic origin is an important one, and couples
undergoing ICSI have the right to be informed
not only of their diminished chances when this is
the case, but also of the possible risk of transmission
to their offspring. Whenever possible, genetic
counseling is important and follow-up of newborns
desirable. However, in view of our present
uncertainties, care should be taken to protect
patients from excessive information, particularly
when no unambiguous conclusions are available.
Another important issue refers to the use of
appropriate nomenclature, previously addressed
by Chemes and Rawe144. We have attempted to
highlight each pathological phenotype with a
denomination that identifies the organelles
involved and the pathogenic mechanisms. The
problem of nomenclature is not a trivial one: the
way in which we speak and write about conditions
is the way we think. If descriptive terms are used,
thoughts will not go beyond appearances. It is
essential to distinguish a dead (immotile) from an
immotile (live) spermatozoon, and to use denominations
that give us the basic understanding of
each pathology. A stump tail can either belong to
a DFS spermatozoon or be the result of tail disintegration
in aging spermatozoa; an amorphous
head can correspond to a lack of acrosome or to
abnormal chromatin maturation and compaction.
The introduction of innovative therapeutic
approaches such as ICSI has revolutionized the
field of reproductive medicine. Besides its obvious
advantages for men with severe male factor infertility,
it has created new concerns about the ethical
and social role of therapeutic interventions.
The possibility of inherited sterility is certainly one
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
highlight each pathological phenotype with a
denomination that identifies the organelles
involved and the pathogenic mechanisms. The
problem of nomenclature is not a trivial one: the
way in which we speak and write about conditions
is the way we think. If descriptive terms are used,
thoughts will not go beyond appearances. It is
essential to distinguish a dead (immotile) from an
immotile (live) spermatozoon, and to use denominations
that give us the basic understanding of
each pathology. A stump tail can either belong to
a DFS spermatozoon or be the result of tail disintegration
in aging spermatozoa; an amorphous
head can correspond to a lack of acrosome or to
abnormal chromatin maturation and compaction.
The introduction of innovative therapeutic
approaches such as ICSI has revolutionized the
field of reproductive medicine. Besides its obvious
advantages for men with severe male factor infertility,
it has created new concerns about the ethical
and social role of therapeutic interventions.
The possibility of inherited sterility is certainly one
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
highlight each pathological phenotype with a
denomination that identifies the organelles
involved and the pathogenic mechanisms. The
problem of nomenclature is not a trivial one: the
way in which we speak and write about conditions
is the way we think. If descriptive terms are used,
thoughts will not go beyond appearances. It is
essential to distinguish a dead (immotile) from an
immotile (live) spermatozoon, and to use denominations
that give us the basic understanding of
each pathology. A stump tail can either belong to
a DFS spermatozoon or be the result of tail disintegration
in aging spermatozoa; an amorphous
head can correspond to a lack of acrosome or to
abnormal chromatin maturation and compaction.
The introduction of innovative therapeutic
approaches such as ICSI has revolutionized the
field of reproductive medicine. Besides its obvious
advantages for men with severe male factor infertility,
it has created new concerns about the ethical
and social role of therapeutic interventions.
The possibility of inherited sterility is certainly one
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
highlight each pathological phenotype with a
denomination that identifies the organelles
involved and the pathogenic mechanisms. The
problem of nomenclature is not a trivial one: the
way in which we speak and write about conditions
is the way we think. If descriptive terms are used,
thoughts will not go beyond appearances. It is
essential to distinguish a dead (immotile) from an
immotile (live) spermatozoon, and to use denominations
that give us the basic understanding of
each pathology. A stump tail can either belong to
a DFS spermatozoon or be the result of tail disintegration
in aging spermatozoa; an amorphous
head can correspond to a lack of acrosome or to
abnormal chromatin maturation and compaction.
The introduction of innovative therapeutic
approaches such as ICSI has revolutionized the
field of reproductive medicine. Besides its obvious
advantages for men with severe male factor infertility,
it has created new concerns about the ethical
and social role of therapeutic interventions.
The possibility of inherited sterility is certainly one
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
144. We have attempted to
highlight each pathological phenotype with a
denomination that identifies the organelles
involved and the pathogenic mechanisms. The
problem of nomenclature is not a trivial one: the
way in which we speak and write about conditions
is the way we think. If descriptive terms are used,
thoughts will not go beyond appearances. It is
essential to distinguish a dead (immotile) from an
immotile (live) spermatozoon, and to use denominations
that give us the basic understanding of
each pathology. A stump tail can either belong to
a DFS spermatozoon or be the result of tail disintegration
in aging spermatozoa; an amorphous
head can correspond to a lack of acrosome or to
abnormal chromatin maturation and compaction.
The introduction of innovative therapeutic
approaches such as ICSI has revolutionized the
field of reproductive medicine. Besides its obvious
advantages for men with severe male factor infertility,
it has created new concerns about the ethical
and social role of therapeutic interventions.
The possibility of inherited sterility is certainly one
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
of the most perplexing paradoxes of our times.
inherited sterility is certainly one
of the most perplexing paradoxes of our times.
