CEDIE 05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
artículos
Título:
Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats.
Autor/es:
COTELLA EVELIN M; MESTRES LASCANO IVAN; LEVIN GLORIA M; SUAREZ MARTA M
Revista:
THE INTERNATIONAL JOURNAL OF NEUROSCIENCE.
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Lugar: YSA; Año: 2009 vol. 119 p. 664 - 680
ISSN:
0020-7454
Resumen:
The aim of this work was to determine the effect of amitriptyline on peripheral outcomes such as plasma epinephrine and norepinephrine concentration and anxiety-like behavior displayed in the plus maze test in adult male Wistar rats under variable chronic stress and daily oral administration of amitriptyline (5 mg/Kg). Animals were previously isolated from the mother for 4.5 h every day for the first 3 weeks of life. Administration of the antidepressant amitriptyline reduced anxiety-like behavior in animals submitted only to chronic stress, but not in early maternally separated subjects or in animals subjected to the two types of stresses.
