CEDIE   05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
artículos
Título:
Aplicaciones de la hormona de crecimiento humana recombinante en HIV. Efectos sobre el aparato inmune
Autor/es:
CASTRO M FABIAN, CASTRO JULIA
Revista:
Prensa Medica Argentina
Editorial:
Prensa Medica Argentina
Referencias:
Lugar: CABA; Año: 2019 vol. 105 p. 253 - 258
ISSN:
0032-745X
Resumen:
Summary:The present work carries out a bibliographic research on the clinical use of RhGH in adult HIV patients in its immunomodulatory role by means of Boolean search in Pubmed of the terms RhGH and HIV in articles of clinical trials, only in adults from 19 or more years of age, until January 2019. There were 27 articles on clinical trials, of which 8 articles were analyzed with the specific objective of investigating the effects on the immune system of RhGH in HIV cases, of which four show good evidence (A1b). The doses tested are different for each trial and range from: 0.7 to 4 mg / day, likewise the duration of it from: 12 weeks to 40 weeks. In all cases, it was concomitant with efficient antiretroviral treatment. These clinical studies show an increase in the CD4 cell count (discrete) and an evident trophic immune effect on the thymus and cell activation (improvement of the immune response). It remains to clarify in future research the dose and duration of optimal treatment, the use in C and / or B viral co-infections and the impact of RhGH on the potential reduction of some of the HIV reservoirs.