CEDIE 05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
artículos
Título:
Role of 20-Hydroxyeicosatetraenoic Acid (20-HETE) in Androgen-Mediated Cell Viability in Prostate Cancer Cells
Autor/es:
SACCA, PAULA; NOWICKI, SUSANA; COLOMBERO, CECILIA; MORMANDI, EDUARDO; PAPADEMETRIO, DANIELA; ALVAREZ, ELIDA
Revista:
Hormones and Cancer
Editorial:
Springer US
Referencias:
Año: 2017 vol. 8 p. 243 - 256
ISSN:
1868-8497
Resumen:
20-Hydroxyeicosatetraenoic acid (20-HETE) is generated intracellularly through the ω-hydroxylation of arachidonic acid by the cytochrome P450 (in humans, CYP4A11 and CYP4F2). 20-HETE induces mitogenic responses in different cancer cells. The aim of this study was to analyze how 20-HETE impacts cell survival, proliferation, and apoptosis in prostate cancer cells. Incubation of the human androgen-sensitive cells (LNCaP) with 1?10 μM HET0016 (a selective inhibitor of 20-HETE synthesis) reduced cell viability by 49*?64%* (*p
