CEDIE 05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
artículos
Título:
Pilot Neonatal Screening Program for Central Congenital Hypothyroidism: Evidence of Significant Detection
Autor/es:
MÉNDEZ, MARIA VIRGINIA; ENACAN, ROSA; SAVENAU, ALEXANDRU; BERGADÁ, IGNACIO; PRIETO, LAURA; GRUÑEIRO-PAPENDIECK, LAURA; REYNAUD, RACHEL; CHIESA, ANA; BRASLAVSKY, DÉBORA; KESELMAN, ANA; JULLIEN, NICOLAS; BRUE, THIERRY
Revista:
Hormone Research in Paediatrics
Editorial:
Karger
Referencias:
Lugar: Basilea; Año: 2017 vol. 88 p. 274 - 280
ISSN:
1663-2818
Resumen:
Background/Aim: Congenital hypothyroidism (CH) is a heterogeneousentity. Neonatal screening programs based onthyrotropin (TSH) determination allow primary CH diagnosisbut miss central CH (CCH). CCH causes morbidity, alerts toother pituitary deficiencies, and is more prevalent than previouslythought. We aimed at developing a pilot neonatalscreening program for CCH detection. Patients and Methods:A prospective 2-year pilot neonatal screening studybased on simultaneous dried blood specimen TSH and thyroxine(T4) measurements was implemented in term newbornsaged 2?7 days. Those with T4 ≤4.5 μg/dL (?2.3 SDS)and TSH
