CEDIE 05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
artículos
Título:
Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation.
Autor/es:
VERÓNICA TRUJILLO; MARÍA LUJAN MASSERONI; GLORIA LEVIN; MARTA MAGDALENA SUAREZ
Revista:
THE INTERNATIONAL JOURNAL OF NEUROSCIENCE.
Editorial:
Taylor & Francis
Referencias:
Año: 2009 vol. 119 p. 1210 - 1227
ISSN:
0020-7454
Resumen:
The aim of this work was to determine the effect of chronic treatment with 5 mg/kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, and anxiety. The plus maze test was performed in order to calculate the anxiety index and catecholamine levels were determined by high-pressure liquid chromatography. Both stress and maternal separation elevated catecholamine levels without affecting anxiety. In the maternally separated stress group, tianeptine decreased epinephrine. Anxiety was reduced in the maternally separated unstressed tianeptine group. Also, all groups showed a tendency to lower anxiety index.
