Body mass index in girls with idiopathic central precocious puberty during and after treatment with GnRH analogues

GRYNGARTEN MG; ROPELATO MG; ARCARI AJ; BALLERINI MG; ESCOBAR ME; FREIRE AV; BERGADÁ I

International Journal of Pediatric Endocrinology

BioMed Central

Lugar: Londres; Año: 2016 vol. 15 p. 1 - 7

1687-9856

AbstractBackground:In girls with Idiopathic Central Precocious Puberty (ICPP) concern has been raised by the potentialimpact of GnRH-analogues (GnRHa) treatment on body weight. We evaluated the effect of GnRHa on Body MassIndex (BMI) in girls with ICPP according to weight status at diagnosis.Methods:One hundred seventeen ICPP girls were divided according to pretreatment weight status in: normalweight (NW), overweight (OW) and obese (OB). BMI at one and two years of treatment was assessed. BMI-SDS of60 patients who reached adult height (AH) was compared to that of 33 ICPP untreated girls.Results:NW girls significantly increased their baseline BMI-SDS at 1 and 2 years of treatment. OW girls only had asignificant increment at one year of treatment while OB girls showed no BMI-SDS change. Patients evaluated atAH (at least four years after GnRHa withdrawal) showeda significant decrease on BMI compared to baseline anda significantly lower BMI than the untreated group.Conclusion:In ICPP girls the BMI increase under GnRHa was inversely related to the pretreatment weight status.In the long term follow-up, no detrimental effect of GnRHa on body weight was observed. BMI-SDS was lower intreated than in untreated girls