CEDIE 05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
artículos
Título:
Assessment of estradiol response after depot triptorelin administration in girls with central precocious puberty
Autor/es:
BALLERINI MG; BERGADÁ I; GRYNGARTEN MG; ESCOBAR ME; FREIRE AV; ARCARI JA; ROPELATO MG
Revista:
Hormone Research in Paediatrics
Editorial:
S. Karger AG
Referencias:
Lugar: Basilea; Año: 2016 vol. 85 p. 58 - 64
ISSN:
1663-2818
Resumen:
ABSTRACT: Background: Estradiol at baseline or after a classical gonadotropin-releasing hormone test did not reflect ovarian steroidogenesis in central precocious puberty (CPP) girls. Aims: To evaluate estradiol response to depot triptorelin, both at start and during therapy to determine how active ovarian steroidogenesis is at pubertal stage and under therapy. Methods: A prospective study was performed in 43 CPP girls. Serum luteinizing hormone and follicle-stimulating hormone at 3 h (LH-3h, FSH-3h) and estradiol at 24 h (E2-24h) after injection of depot triptorelin 3.75 mg were measured, at first dose and at 3, 6, 12, 18 and 24 months of treatment. Results: E2-24h after depot triptorelin was >100 pg/ml after the first dose. Estradiol response (E2-24h) fell to levels
