CEDIE   05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
artículos
Título:
Effects of early maternal separation and lesion of ADTN on anxiety and hypophyso-adrenal system activity in male rats.
Autor/es:
BARCENA ESQUIVEL BARBARA; LEVIN GLORIA; RIVAROLA MARIA ANGELICA; SUAREZ MARTA MAGDALENA
Revista:
INTERNATIONAL JOURNAL OF NEUROSCIENCE
Editorial:
Taylor & Francis
Referencias:
Año: 2008
Resumen:
The present study investigated the effect of early maternal separation on anxiety and hypophyso-adrenal system activity to ADTN lesion in male rats as adults in order to compare this with previous results with female rats . Male rats were isolated 4.5h daily, during the first three weeks of life and tested as adults. Thirty days after ADTN lesion we found that ACTH plasma levels were affected neither by maternal separation nor by ADTN lesion. Plasma corticosterone concentration was increased with lesion of the ADTN in maternally-separated rats. A significant increase in plasma catecholamine concentration was induced by early maternal separation. In ADTN-lesioned rats, plasma norepinephrine concentration was significantly lower than in the respective sham-lesioned groups. In terms of anxiety, there were no significant effects of early experience. However, the ADTN lesion tended to decrease anxiety-related behavior.