Assessment of Estradiol Response after Depot Triptorelin Administration in Girls with Central Precocious Puberty

ANALÍA VERÓNICA FREIRE ; MIRTA GRACIELA GRYNGARTEN ; MARÍA GABRIELA BALLERINI; ANDREA JOSEFINA ARCARI

hormone research in pediatrics

Karger AG

Lugar: Basilea; Año: 2015 p. 58 - 64

BACKGROUND:Estradiol at baseline or after a classical gonadotropin-releasing hormone test did not reflect ovarian steroidogenesis in central precocious puberty (CPP) girls.AIMS:To evaluate estradiol response to depot triptorelin, both at start and during therapy to determine how active ovarian steroidogenesis is at pubertal stage and under therapy.METHODS:A prospective study was performed in 43 CPP girls. Serum luteinizing hormone and follicle-stimulating hormone at 3 h (LH-3h, FSH-3h) and estradiol at 24 h (E2-24h) after injection of depot triptorelin 3.75 mg were measured, at first dose and at 3, 6, 12, 18 and 24 months of treatment.RESULTS:E2-24h after depot triptorelin was >100 pg/ml after the first dose. Estradiol response (E2-24h) fell to levels