CEDIE   05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
artículos
Título:
Serum concentration of 17 alpha hydroxyprogesterone in children from birth to adolescence.
Autor/es:
BALLERINI M.G ; CHIESA A.; MORELLI C; FRUSTI M; ROPELATO M.G.
Revista:
HORMONE RESEARCH
Editorial:
KARGER
Referencias:
Lugar: Basel; Año: 2014 vol. 81 p. 118 - 125
ISSN:
0301-0163
Resumen:
BACKGROUND: Reference intervals (RI) of serum 17á- hydroxyprogesterone (17OHP) are useful to confirm congenital adrenal hyperplasia (CAH) in neonates with abnormal screening results and nonclassical forms of CAH in symptomatic children. We aimed to establish serum 17OHP RI in normal children and adolescents using a current 17OHP radioimmunoassay (RIA). METHODS: Serum 17OHP was measured via a current RIA (Diasource) in children, i.e. 111 infants aged 1 year, covering the whole analytical range, were simultaneously measured to compare 17OHP RIA from Diagnostic System Laboratories (DSL) (withdrawn) and Diasource by Passing Bablok linear regression and ratio plot. The equation obtained was used to correct our own previous RI (DSL RIA) for infancy for the Diasource RIA. Samples from infants aged 1 year by ANOVA. RESULTS: E-17OHP as measured via the Diasource RIA was significantly lower than NE-17OHP in infants aged