TESTICULAR FUNCTION DURING ADOLESCENCE IN BOYS WITH TYPE 1 DIABETES MELLITUS (T1D): ABSENCE OF HYPOGONADISM AND DIFFERENCES IN ENDOCRINE PROFILE AT THE BEGINNING AND END OF PUBERTY

ROCHA A; IÑIGUEZ G; GODOY C; GAETE X; LÓPEZ P; LORETI N; CAMPO S; REY RA; CODNER E

PEDIATRIC DIABETES

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2014 vol. 15 p. 198 - 205

1399-543X

ABSTRACT: Background: Conflicting results regarding testicular function in adults with type 1 diabetes (T1D) have been reported, but little is known about Leydig and Sertoli cell function during puberty in boys treated with multiple daily insulin doses. Objective: The aim of this study was to assess testicular function during adolescence in boys with T1D. Methods: Pubertal boys with T1D (n = 69) and healthy control boys (C group; n=100) who were 10-18 years were studied. Both groups were matched by pubertal stage, age and BMI. Total testosterone (TT), calculated free testosterone (cfT), SHBG, inhibin B, AMH and gonadotropin levels were determined. Results: At the beginning of puberty, the T1D group had higher levels of SHBG (P=0.003) and similar androgen levels than the C group. At the end of puberty, higher TT and cfT were observed in T1D compared to the C boys (P