CEDIE   05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
artículos
Título:
Prediction of reproductive outcomes according to different serum anti-Müllerian hormone levels in females undergoing intracystoplasmic sperm injection
Autor/es:
BRUGO OLMEDO, S.; DE VIDENTIITS, S.; DE MARTINO, E.; BEDECARR¨¢S, P.; BLANCO, A.M.; FREIRE, A.V.; BUFFONE, M.; REY, R.
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Lugar: San Francisco; Año: 2013 vol. 8 p. 75685 - 75685
ISSN:
1932-6203
Resumen:
Background and aim of the study: Serum anti-M¨¹llerian hormone (AMH) is a reliable marker of ovarian reserve, and it has been shown to be correlated with reproductive outcomes in grouped analyses. However, practical data is scarce for the physician and the patients to predict these outcomes in an individual couple according to serum AMH measured prior to assisted reproduction technology (ART) procedures. Study design: To address this question, we performed an analytic observational study including 145 females undergoing intracytoplasmic sperm injection (ICSI) in a single center. Results were analyzed according to serum AMH; subgroup analyses were performed by grouping patients according to patient¡¯s age and FSH levels. Results: The risk of cycle cancelation decreased from 64% in patients with serum AMH ¡Ü3 pmol/L (0.42 ng/mL) to 21% with AMH ¡Ý15 pmol/L (2.10 ng/mL). Cycle cancelation occurred in approximately 2/3 of the patients with AMH ¡Ü 3 pmol/L irrespective of the FSH level. However, with higher AMH values the risk of cycle cancelation decreased more significantly in patients with normal FSH. The rate of good response increased from almost null in patients with AMH ¡Ü3 pmol/L to 61% in those with AMH ¡Ý15 pmol/L. The positive correlation between good response and AMH was also significant, but with lower absolute rates, when patients were grouped according to their age or FSH levels. Pregnancy rate increased moderately, but significantly, from 31% with AMH ¡Ü3 pmol/L to 35% with AMH ¡Ý15 pmol/L. Conclusions: We provide estimates of reproductive outcomes according to individualized values of serum AMH, in general and in subgroups according to patient¡¯s age or serum FSH, which are helpful for the clinician and the couple in their decision making about starting an assisted reproductive treatment.