CEDIE   05498
CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Unidad Ejecutora - UE
artículos
Título:
Controversial role of inhibin alpha-subunit gene in the aetiology of premature ovarian failure (POF).
Autor/es:
SUNDBLAD V; CHIAUZZI VA; ANDREONE L; CAMPO S; CHARREAU E; DAIN L
Revista:
HUMAN REPRODUCTION
Referencias:
Año: 2006 p. 1154 - 1160
ISSN:
0268-1161
Resumen:
BACKGROUND: Premature ovarian failure (POF) is a heterogeneous syndrome with multicausal pathogenesis, characterized by amenorrhea before the age of 40. Inhibin-a gene is proposed as a candidate gene for POF, due to its role in negative feedback control of hypophyseal FSH. METHODS: We studied polimorphism C129T and substitution G769A of inhibin-a gene in 52 POF patients and 136 controls. RESULTS: We found no significant differences in risk of POF development for the T allele of polymorphism C129T when we compared I-POF either with C <40 or with C>40 (OR TvsC; I-POF vs C<40   = 1.82; IC 95%= 0.88-3.75 ; OR TvsC; I-POF vs C>40   = 1.07; IC 95%= 0.53-2.16). The implication of this polymorphism in serum inhibin levels was analysed in 42 control women, and no significant differences (p>0.05) were found between CC and CT+TT groups, when comparing either mid-follicular phase inhibin peptide values (Pro-aC and Inh B) or mid-luteal phase values (Pro-aC and Inh A). Heterozygocity for substitution G769A was found in 8/135 controls and in only 1/52 POF woman. Presence of this substitution in a relevant number of control subjects is herein described for the first time. CONCLUSION: Our results might indicate that C129T and G769A variants in INH-a gene may not be associated to POF disease.