Propylthiouracil-induced hepatotoxicity and death. Hopefully, never more

MALOZOWSKI S; ,CHIESA A

JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM

ENDOCRINE SOC

Lugar: Springfield, Ill; Año: 2010 vol. 95 p. 3161 - 3163

0021-972X

Addressing the dissimilar toxicities of the two most commonly used antithyroid medications, propylthiouracil (PTU) and methimazole (MMI), and focusing particularly on hepatotoxicity and death in children, Rivkees and Szarfman bring to the forefront an issue that time and time again has fallen off our radar screen: the use of PTU can result in tragic consequences and should never be used in children (1). The same statement could be made for adults, with the exception of use during early pregnancy when PTU use may avoid the potential for fetal malformations that may occur with MMI (2). However, the MMI teratogenic link seems tenuous. commonly used antithyroid medications, propylthiouracil (PTU) and methimazole (MMI), and focusing particularly on hepatotoxicity and death in children, Rivkees and Szarfman bring to the forefront an issue that time and time again has fallen off our radar screen: the use of PTU can result in tragic consequences and should never be used in children (1). The same statement could be made for adults, with the exception of use during early pregnancy when PTU use may avoid the potential for fetal malformations that may occur with MMI (2). However, the MMI teratogenic link seems tenuous. commonly used antithyroid medications, propylthiouracil (PTU) and methimazole (MMI), and focusing particularly on hepatotoxicity and death in children, Rivkees and Szarfman bring to the forefront an issue that time and time again has fallen off our radar screen: the use of PTU can result in tragic consequences and should never be used in children (1). The same statement could be made for adults, with the exception of use during early pregnancy when PTU use may avoid the potential for fetal malformations that may occur with MMI (2). However, the MMI teratogenic link seems tenuous. commonly used antithyroid medications, propylthiouracil (PTU) and methimazole (MMI), and focusing particularly on hepatotoxicity and death in children, Rivkees and Szarfman bring to the forefront an issue that time and time again has fallen off our radar screen: the use of PTU can result in tragic consequences and should never be used in children (1). The same statement could be made for adults, with the exception of use during early pregnancy when PTU use may avoid the potential for fetal malformations that may occur with MMI (2). However, the MMI teratogenic link seems tenuous. ddressing the dissimilar toxicities of the two most commonly used antithyroid medications, propylthiouracil (PTU) and methimazole (MMI), and focusing particularly on hepatotoxicity and death in children, Rivkees and Szarfman bring to the forefront an issue that time and time again has fallen off our radar screen: the use of PTU can result in tragic consequences and should never be used in children (1). The same statement could be made for adults, with the exception of use during early pregnancy when PTU use may avoid the potential for fetal malformations that may occur with MMI (2). However, the MMI teratogenic link seems tenuous.