Serology and longevity of immunity against echinococcus granulosus in sheep and llama induced by an oil based eg95 vaccine

MOSSELLO MAFALDA; GERTISER MARIA LAURA; ECHENIQUE MARCELO ALEJANDRO; HEATH DAVID; JENSEN OSCAR; AVILA HECTOR GABRIEL ; ROMERO SANDRA; BARRIOS JOSE RAMON; POGGIO THELMA VERONICA; IRIARTE JORGE; SERAFINO JUAN JAVIER; DOMINGUEZ ERNESTO

PARASITE IMMUNOLOGY

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2016

0141-9838

An oil-based formulation of the EG95 vaccine to protect grazing animals against infectionwith Echinococcus granulosus was formulated in Argentina. The efficacy of the vaccine wasmonitored by serology in sheep and llama (Lama glama), and was compared to the serologyin sheep previously published using a QuilA-adjuvanted vaccine. Long-term efficacy wasalso tested in sheep by challenging with E. granulosus eggs of the G1 strain 4 years after thebeginning of the trial. The serological results for both sheep and llama were similar to thosedescribed previously, except that there was a more rapid response after the first vaccination.A third vaccination given after 1 year resulted in a transient boost in serology that lasted forabout 12 months, which was similar to results previously described. Sheep challenged after 4years with 3 vaccinations presented 84.2% reduction of live cysts counts compared withcontrol group, and after a fourth vaccination prior to challenge this reduction was 94.7%. Theoil-based vaccine appeared to be bio-equivalent to the QuilA vaccine.