CIEM   05476
CENTRO DE INVESTIGACION Y ESTUDIOS DE MATEMATICA
Unidad Ejecutora - UE
artículos
Título:
Pareto front for chemotherapy schedules
Autor/es:
BARREA, ANDRES - HERNANDEZ MATIAS
Revista:
Applied Mathematical Sciences
Editorial:
Hikari Ltd
Referencias:
Lugar: Sofia; Año: 2012 vol. 6 p. 5789 - 5800
ISSN:
1312-885X
Resumen:
In this paper we consider a multi-objective approach to chemother-apy optimization. We assume that the dynamics of the tumor are mod-eling for the stochastic Gompertz growth model with a linear cell-losseffect . We consider fuzzy constraints for the problem. The primaryobjective is to eradicate the tumor (curative treatment) , the secondobjective of cancer chemotherapy is to prolong the patient survival .time maintaining a reasonable quality of life during the palliation pe-riod. Numerical results are presented for a particular case (bladdercancer).