Looking for a Greener Approach to the Reaction Synthesis of Oxo and Thio Hydantoin Derivatives

FAILLACE M. S.; DO SANTOS DA SILVA A. P.; MENDES DE FREITAS R. ; PELÁEZ W. J. ; ARGÜELLO G. A.

Golden

Otro; 2015 ACS Summer School on Green Chemistry & Sustainable Energy; 2015

American Chemical Society

Hydantoin derivatives have numerous and interesting biological activities like cytotoxicity to cancerous cells between others. These applications force us to propose alternative synthetic methodologies, more economic and eco-friendly.For the previous reason, we aimed to find the very best reaction synthesis condition of (thio) hydantoin derivatives, looking for the synthesis of a novel family of compounds.The compounds were synthetized by Microwave Assisted Organic Synthesis using a Monowave 300 from Anton Paar. The reaction conditions were adjusted until find the best condition considering a balance between the yields and the impact to the environment. In order to quantify the yield of the reaction synthesis, the product were measured by UV spectroscopy. On the other hand, the compounds were characterized by RMN spectroscopy and CG-MS spectrometry.