Surface activity of L- ascorbic acid derivatives

MILAGRO MOTTOLA; MARTÍN VILLANUEVA; MARÍA LAURA FANANI; RAQUEL VICO

Carlos Paz, Córdoba

Congreso; XLII Reunión Anual de la Sociedad Argentina de Biofísica; 2013

Sociedad Argentina de Biofísica

L-ascorbic acid derivatives are molecules of potential pharmacological interest (as well as alimentary and cosmetic) due to its antioxidant properties and amphiphilic nature. These vitamin C derivatives (ASCn n= 10, 12, 14) were synthesized according to a modified method of the main procedure already reported in literature [1] and were compared with the commercial derivative ASC16. These molecules were characterized through 1H 13C NMR and IR, showing stability during three weeks. We found that, contrary to ASC10 and ASC12, ASCn with n= 14 and 16 form stable Langmuir monolayers at room temperature. ASC16 films show phase transition from a liquid-expanded (LE) to a liquid-condensed (LC) or crystalline phase, whereas the other derivatives presents only a LE phase. All these compounds have a complex surface behavior and display a favorable penetration into phospholipid monolayers with strong interaction among them.