Microwave assisted synthesis of potentially bioactive heterocycles

FABRIZIO POLITANO; ELBA I. BUJÁN

Golden - Colorado

Otro; 2013 ACS Summer School on Green Chemistry and Sustainable Energy; 2013

American Chemical Society

Several compunds derived from benzimidazole N-oxides show pharmacological and pesticide properties. For this reason, it is important to have efficient and sustainable synthetic routes. Available synthetic methods generally include several steps since Noxides have not been obtained by direct oxidation of benzimidazoles. Most of the methods include cyclization in basic medium of 2- nitroanilines derivatives with various substituents on the amino group and on the aromatic ring. In classical organic chemistry, huge amounts of toxic solvents are used for isolation and purification of products. In addition, the energetic consumption for heating the different reactions is one of the great problems in organic methods. Considering these two concerns, we focus in the development of new synthetic procedures in order to obtain benzimidazole and benzimidazole N-oxides derivatives reducing the amount of organic solvents, or in solventless conditions, and using microwave radiation as energy source. The research group has developed an efficient synthetic method, but from the point of view of green chemistry we believe that it should be better.