INFIQC   05475
INSTITUTO DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
LAYERED DOUBLE HYDROXIDES-AINEs HYBRIDS: PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO DRUG RELEASE
Autor/es:
RICARDO ROJAS; CARLA E. GIACOMELLI; RUBEN H. MANZO; ALVARO JIMÉNEZ-KAIRUZ
Lugar:
Rosario
Reunión:
Congreso; 2ª Reunión internacional de ciencias farmacéuticas; 2012
Institución organizadora:
Universidad Nacional de Rosario
Resumen:
Layered double hydroxides (LDHs) are inorganic solids with bidimensional structures and anion exchange properties that are currently used as inert excipients and antacids in pharmaceutical dosage forms1. Furthermore, the number of reports studying LDHs in drug delivery design has markedly increased in the last years due to their capacity to incorporate different pharmaceutically active drugs (antiinflamatories, antibiotics, antihypertensives, anticancerigens)2 and biomolecules (amino acids, peptides and DNA)3. Nevertheless, studies concerning LDHs as drug carriers have centered their attention on the incorporation of diverse anionic drugs and the structural characterization of the synthesized material while the study of their biopharmaceutical behavior has been almost exclusively restricted to drug release from particulate solid dispersions4. The aims of this work are the synthesis of LDH-anionic drug (LDH-D) hybrids, the determination of relevant physicochemical properties and the evaluation of in vitro drug release from LDH-D hybrids formulated as hydrophilic matrices. Particularly, LDHs of Mg and Al loaded with ibuprofen (Ibu), naproxen (Nap) or ketoprofen (Ket) were studied to correlate their structure and interfacial properties with their drug release profiles in simulated gastric (SGF) and intestinal (SIF) fluids.