INFIQC   05475
INSTITUTO DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Stereoselective Bioreduction of α,α-Dihalogenated Acetophenone Derivatives with Alcohol Dehydrogenases (ADHs): Access to Interesting Compounds
Autor/es:
KINGA KEDZIORA; FABRICIO R. BISOGNO; BARBARA GRISCHEK; IVAN LAVANDERA; VICENTE GOTOR-FERNÁNDEZ; WOLFGANG KROUTIL; VICENTE GOTOR
Lugar:
Delft
Reunión:
Conferencia; Frontiers in White Biotechnology; 2011
Institución organizadora:
TUDelft
Resumen:
ADHs catalyze the stereoselective bioreduction of ketones and aldehydes allowing the production of a large variety of enantiopure alcohol derivatives.1 Although ADHs have been applied successfully in the biotransformation of many compounds, their application to α,α-dihalogenated ketones has not been widely investigated yet. Encouraged by previous results obtained in our research group applied to the bioreduction of α-halogenated ketones,2,3 we have decided to extend our studies synthesizing and reducing α,α-dihalogenated acetophenone derivatives by means of alcohol dehydrogenases (Scheme 1).Scheme 1. Experimental model for the bioreduction of α,α-dihalogenated ketonesBecause of the high reactivity of 2,2-dihalogenated-1-phenylethanol derivatives, these enantiopure compounds can be employed as ideal building-blocks of enantioenriched high-added valuable compounds.