Alternative method with amperometric detection for the determination of ranitidine

V. PFAFFEN; P.I. ORTIZ

INDUSTRIAL AND ENGINEERING CHEMISTRY

AMER CHEMICAL SOC

Lugar: Estados Unidos; Año: 2010 vol. 49 p. 4026 - 4030

0019-7866

An alternative, simple and reliable FIA-amperometric method for ranitidine quantification was developed. A working glassy carbon electrode and a Ag½AgCl½NaCl (3M) reference electrode were used. The determination is based on the electrochemical oxidation of ranitidine at 1.2 V in phosphate buffer solution (pH 7.2). The determination of ranitidine in the range of 1 x 10-6-2 x 10-5 M was possible with a sampling frequency of 120 h-1. The method was validated and satisfactorily applied to the determination of ranitidine in pharmaceutical formulations with a low limit of detection (LOD) (6 x 10-7 M) and a quantitative recovery with no interferences from excipients. The results compare favorably with those obtained by the liquid chromatographic method of the US Pharmacopoeia.