INFIQC 05475
INSTITUTO DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Weeds as biocatalysts in the stereoselective synthesis of chiral phenylethanols used as key intermediates for pharmaceuticals
Autor/es:
DANIELA L. BORDON,; LEONARDO D. VILLALBA; MARIO L. AIMAR; JUAN J. CANTERO; ANA M. VÁZQUEZ; STELLA M. FORMICA; C. R. KRAPACHER; LAURA I. ROSSI
Revista:
Biocatalysis and Agricultural Biotechnology
Editorial:
Elsevier
Referencias:
Año: 2015 vol. 4 p. 493 - 499
ISSN:
1878-8181
Resumen:
This paper describes the search for novel vegetal biocatalysts for the stereoselective reduction of pro-chiral phenylketones. In this study, twenty native weeds were tested and Eryngium horridum Malme (Apiaceae) was proven to be an effective biocatalyst for the stereoselective reduction of acetophenone to (S)-1-phenylethanol (96%conversion, >99.9 e.e.%). Using this biocatalyst, fourteen chiral (S)-pheny-lethanols with excellent enantiomeric excesses (>98%) and variable conversions (30?100%) were obtained.
